EGFR/COX-2-IN-2 (Compound 10a) is a dual inhibitor targeting epidermal growth factor receptor (EGFR) (IC50= 6.0 µM) and cyclooxygenase-2 (COX-2) (IC50=50 µM). EGFR/COX-2-IN-2 induces S-phase cell cycle arrest and apoptosis. EGFR/COX-2-IN-2 is promising for research of cancers and inflammation-related diseases[1].
Molecular Weight:
432.49
Formula:
C23H20N4O3S
Target:
Apoptosis,COX,EGFR
Application Notes:
MCE Product type: Reference compound
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