PKM2-IN-11 is a PKM2 inhibitor (IC50 = 0.363 µM). PKM2-IN-11 has dual mechanisms involving pyruvate kinase M2 (PKM2) inhibition and microtubule stabilization. PKM2-IN-11 can decrease PKM2 protein levels in MCF-7 cells. PKM2-IN-11 can slightly reduce reactive oxygen species (ROS) levels and significantly increase early apoptotic cells. PKM2-IN-11 induces G2/M phase arrest. PKM2-IN-11 can be used for the study of breast cancer[1].
Molecular Weight:
462.28
Formula:
C21H19IO4
Target:
Apoptosis,Microtubule/Tubulin,Pyruvate Kinase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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