PPARgamma agonist 20 is a potent, orally active PPAR-gamma agonist. PPARgamma agonist 20 effectively increases antioxidant defenses (SOD, GSH) and reduces lipid peroxidation. PPARgamma agonist 20 can upregulate of Pparg, Glut4, and AdipoQ, suppresses of TNF-alpha, IL-6, and NF-kappaB p65. PPARgamma agonist 20 significantly lowers fasting blood glucose, improving glucose tolerance, and restoring metabolic balance in Streptozotocin (HY-13753)-Nicotinamide (HY-B0150)-induced diabetic rats. PPARgamma agonist 20 can be used for the study of type 2 diabetes[1].
