Tubulin polymerization/P-gp-IN-1 Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-178466
Supplier Catalog Number:
HY-178466
Alternative Catalog Number:
MCE-HY-178466-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Tubulin polymerization/P-gp-IN-1 is a Tubulin polymerization/P-gp dual inhibitor. Tubulin polymerization/P-gp-IN-1 inhibits tubulin polymerization and induces G2/M arrest and apoptosis. Tubulin polymerization/P-gp-IN-1 reverses MDR by inhibiting P-gp efflux function. Tubulin polymerization/P-gp-IN-1 has dual functions: direct antitumor activity and reversal of P-gp-mediated Cisplatin (HY-17394) resistance. Tubulin polymerization/P-gp-IN-1 stable binds to the tubulin CBS (deltaG = -12.4 kcal/mol) and the P-gp hydrophobic lumen (deltaG = -10.8 kcal/mol). Tubulin polymerization/P-gp-IN-1 can be used for the study of drug-resistant cervical cancer[1].
Molecular Weight:
658.62
Formula:
C36H29F3N2O7
Target:
Apoptosis,Microtubule/Tubulin,P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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