LIFR/GPBAR1 modulator 1 is an orally active, potent GPBAR1 agonist (EC50 = 0.2 µM) and LIFR inhibitor (IC50 = 7.9 µM). LIFR/GPBAR1 modulator 1 upregulates leukaemia inhibitory factor (LIF)-mediated mRNA expression of LIFR and GPBAR1 and significantly reduces the expression of pro-fibrosis markers (COL1A1, ASMA, and TGFbeta), and reduces TIMP1 expression and increases MMP9 expression. LIFR/GPBAR1 modulator 1 can be used for the study of human fibrotic disorders[1].
Molecular Weight:
461.59
Formula:
C32H31NO2
Target:
G protein-coupled Bile Acid Receptor 1,MMP,TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound1
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