PDE1-IN-11 (Compound 5cc) is an orally active and highly selective PDE1A1 inhibitor. PDE1-IN-11 increases intracellular cAMP and cGMP levels, activating the PKA-CREB and NO-cGMP-PKG signaling pathways, promoting osteoblast differentiation and bone formation, while suppressing osteoclastogenesis and bone resorption. PDE1-IN-11 is promising for research of postmenopausal osteoporosis (PMO) and other bone metabolism disorders[1].
Molecular Weight:
262.37
CAS Number:
[86009-41-8]
Formula:
C14H18N2OS
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound1
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