SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kalpha and PI3Kdelta), 2.02 nM (PI3Kgamma), 12.69 nM (PI3Kbeta) and 114 nM (HDAC1). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3). SJY26 can be used for the studies of non-small cell lung cancer and leukemia[1].
Molecular Weight:
680.68
Formula:
C35H26F2N6O5S
Target:
Akt,HDAC,Histone Methyltransferase,PI3K
Application Notes:
MCE Product type: Reference compound
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