ZJK-807 is a highly effective and selective PROTAC degrader targeting KRASG12D (DC50 = 79.5 nM in AsPC-1 cells). ZJK-807 shows minimal impact on wild-type KRAS or other mutants (G12C/S/V, G13D), inducing mutant-specific cytotoxicity. ZJK-807 suppresses RAS/MAPK signaling and uniquely modulates TNF signaling and eukaryotic ribosome biogenesis. ZJK-807 can be used for the study of KRAS-driven pancreatic cancer. Yellow: KRASG12D ligand (HY-W087383), Green: E3 ligase CRBN ligand (HY-178507), Black: Linker (HY-178506)[1].
Molecular Weight:
906.98
Formula:
C50H48F2N10O5
Target:
p38 MAPK,PROTACs,Ras,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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