WCY-8-67 is an orally active and selective USP5 inhibitor, with an IC50 value of 1.33 µM. WCY-8-67 induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways in vitro. WCY-8-67 inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 can be used for the study of acute myeloid leukemia[1].
Molecular Weight:
449.57
CAS Number:
[3052618-54-6]
Formula:
C25H32FN7
Target:
Akt,Apoptosis,Deubiquitinase,JAK,PI3K,STAT
Application Notes:
MCE Product type: Reference compound
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