Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFalpha release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1beta (IC50: 0.2 µM) in Uric acid (HY-B2130)-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases[1].
Molecular Weight:
516.60
CAS Number:
[1984784-10-2]
Formula:
C30H28N8O
Target:
ERK,Interleukin Related,MAP3K,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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