BION106 is a dihydrofolate reductasethymidylate synthase (DHFR-TS) PROTAC degrader. BION106 exhibits extremely strong anti-malarial activity with a Ki and toxicity of 2.68 nM and 0.2 µM against Plasmodium falciparum, and > 100 µM and 44.2 µM in mammalian cells. BION106 can be used for the study of antimalarial parasites (Pink: DHFR-TS ligand (HY-15676), Blue: Idasanutlin ligand (HY-153007), Black: Linker (HY-W021401))[1].
Molecular Weight:
1133.12
CAS Number:
[3077918-44-3]
Formula:
C57H69Cl2F2N9O9
Target:
Dihydrofolate reductase (DHFR) ,Parasite,PROTACs
Application Notes:
MCE Product type: Reference compound
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