GI261520A is a egfr/erbb2 dual inhibitor. GI261520A inhibits PhoQ phosphorylation dose-dependently. GI261520A can downregulate the activity levels of PhoP/PhoQ. GI261520A inhibits pagC reporter expression levels with an IC50 of 3.2 µM. GI261520A inhibits PhoQc autokinase activtiy by 80%. GI261520A can permeate the eukaryotic plasmatic and vascular cell membranes and reach intravacuolar Salmonella to block intramacrophage proliferation[1].
Molecular Weight:
357.41
CAS Number:
[179248-64-7]
Formula:
C22H19N3O2
Target:
Bacterial,EGFR
Application Notes:
MCE Product type: Reference compound
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