PKM2-IN-12 is an orally active PKM2 inhibitor with an IC50 of 10 nM. PKM2-IN-12 inhibits COLO-205 cell proliferation and migration, arrests the cell cycle, and induces apoptosis. PKM2-IN-12 significantly reduces cellular levels of lactate, pyruvate, and ROS. PKM2-IN-12 directly kills cancer cells and restores disrupted gut microbiota balance in mice model. PKM2-IN-12 can be used to study colorectal cancer[1].
Molecular Weight:
465.35
Formula:
C23H14Cl2N4OS
Target:
Apoptosis,Endogenous Metabolite,Pyruvate Kinase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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