BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317), Blue: CRBN ligand (HY-179305), Black: Linker)[1].
Molecular Weight:
715.24
CAS Number:
[3084696-50-1]
Formula:
C36H43ClN10O4
Target:
BCL6,PROTACs
Application Notes:
MCE Product type: Reference compound
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