AGU661 is a Microsomal prostaglandin E2 synthase 1 (mPGES-1) inhibitor with an IC50 of 0.22 nM. AGU661 lowers PGE2 formation in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. AGU661 has unfavorable physicochemical properties with poor metabolic stability and strong plasma protein binding tendencies. AGU661 into PLGA-based NPs significantly enhances its bioactivity. AGU661 can be used for inflammatory disorders research[1].
Molecular Weight:
594.94
CAS Number:
[3038861-75-2]
Formula:
C28H21ClF6N4O2
Target:
PGE synthase
Application Notes:
MCE Product type: Reference compound
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