LD-110 triTFA is a highly efficient and effective LSD1 PROTAC degrader (DC50 = 0.44 µM). LD-110 triTFA promotes LSD1 degradation and increases the level of H3K4 dimethylation in a ubiquitin-proteasome-dependent manner. LD-110 triTFA inhibits the growth and survival of multiple esophagus squamous cancer cell (ESCC) lines by inducing apoptosis. LD-110 triTFA can be used for the study of esophagus squamous cancer[1].
Molecular Weight:
1081.89
Purity:
99.5600
Formula:
C48H44F9N7O12
Target:
Apoptosis,Histone Demethylase,PROTACs
Application Notes:
MCE Product type: Reference compound1
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