TS-IN-8 is a potent thymidylate synthase (TS) inhibitor. TS-IN-8 can induce apoptosis and cause cell cycle arrest at the G2/M in MCF-7 cells. TS-IN-8 can induce nuclear morphological changes. TS-IN-8 can increase intracellular reactive oxygen species (ROS) levels. TS-IN-8 can activate intrinsic apoptosis pathways by regulating apoptosis-related proteins such as the bax/bcl-2 ratio and caspase activation. TS-IN-8 can be used for the study of breast cancer[1].
Molecular Weight:
389.44
Formula:
C19H20FN3O3S
Target:
Apoptosis,Bcl-2 Family,Caspase,Reactive Oxygen Species (ROS),Thymidylate Synthase
Application Notes:
MCE Product type: Reference compound
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