DHODH-IN-32 (Compound A1) is a DHODH inhibitor. DHODH-IN-32 shows significant cytotoxicity against NCI-60 cell lines, especially being sensitive to breast cancer, prostate cancer and leukemia cell lines. DHODH-IN-32 can induce cell apoptosis by activating the Caspase pathway. DHODH-IN-32 causes G0/G1 phase cell cycle arrest and inhibits cellular metabolism by ROS. DHODH-IN-32 exhibits significant anti-tumor properties in mouse breast cancer models. DHODH-IN-32 can be used for the study of breast cancer[1].
Molecular Weight:
307.13
Formula:
C10H7F3N2OSe
Target:
Apoptosis,Caspase,Dihydroorotate Dehydrogenase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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