IA107 is a potent, selective, and allosteric IRE1alpha RNase (IC50 = 16 nM (non phosphorylated), IC50 = 9 nM (phosphorylated)) inhibitor. IA107 can inhibit endoplasmic reticulum stress-induced XBP1 mRNA splicing and protein expression, and has no cytotoxicity[1].
Molecular Weight:
386.24
Formula:
C19H16BrNO3
Target:
IRE1
Application Notes:
MCE Product type: Reference compound
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