Anti-infective agent 12 (Compound A09) is a competitive inhibitor of type I signal peptidease (SPase I), with an IC50 of 4.475 µM and a Kd of 16.3 µM. Anti-infective agent 12 has the ability to disrupt bacterial membranes and remove biofilms. Anti-infective agent 12 exhibits potent bactericidal activity against Gram-positive bacteria, with MIC values of 4, 4, 8, and 8 µg/mL for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus suis, respectively. Anti-infective agent 12 remains effective against multi-drug resistant strains, but has weaker activity against Gram-negative bacteria (such as Escherichia coli and Salmonella), with MIC values > 64 µg/mL. Anti-infective agent 12 has low hemolytic activity and shows significant efficacy in mouse skin infection models[1].
Molecular Weight:
637.81
Formula:
C35H51N5O6
Target:
Bacterial
Application Notes:
MCE Product type: Reference compound
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