FXR agonist 13 is a selective, orally active, potent FXR agonist (EC50 = 0.097 µM) and has favorable hepatic microsomal metabolic stability. FXR agonist 13 exhibits moderate affinity for FXR-LBD upon direct binding (KD = 14.74 µM). FXR agonist 13 displays good selectivity against related nuclear receptors, including LXRalpha/beta, PPARalpha/gamma/delta, PXR, and TGR5. FXR agonist 13 can be used for the study of metabolic-associated steatohepatitis (MASH)[1].
Molecular Weight:
533.90
Formula:
C26H20ClF4N3O3
Target:
FXR
Application Notes:
MCE Product type: Reference compound
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