PROTAC ERalpha Degrader-13 is an orally active PROTAC molecule that efficiently and selectively degrades ERalpha (DC50 = 3.78 nM). PROTAC ERalpha Degrader-13 has the characteristics of strong anti proliferation (IC50 = 0.6 nM), induction of apoptosis, and overcoming drug resistance in MCF-7 cells. PROTAC ERalpha Degrader-13 has good safety and no significant organ toxicity. PROTAC ERalpha Degrader-13 can be used for cancer research. (Pink: ERalpha Ligand (HY-12864), Blue: VHL Ligand (HY-125845), Black: Linker (HY-W040168))[1]
Molecular Weight:
1018.63
Formula:
C55H61ClFN7O7S
Target:
Apoptosis,Estrogen Receptor/ERR,PROTACs
Application Notes:
MCE Product type: Reference compound
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