PROTAC RET Degrader 1, CAS [[2760847-82-1]] Preis auf Anfrage

Product Overview

• Article Name: PROTAC RET Degrader 1, CAS [[2760847-82-1]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-178964
• Supplier Catalog Number: HY-178964
• Alternative Catalog Number: MCE-HY-178964-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PROTAC RET Degrader 1 (Compound 20) is an orally active and blood-brain barrier-crossing RET PROTAC degrader with DC50 values for RET (WT), RET (G810S), RET (G810C), and RET (G810R) of 1.7, 3, 12, and 21 nM, respectively. PROTAC RET Degrader 1 exhibits potent anti-proliferative activity in cancer cell lines carrying oncogenic RET fusions (such as KIF5B-RET, CCDC6-RET) or mutations (such as RET (C634W)). PROTAC RET Degrader 1 shows significant anti-tumor activity in human tumor xenograft (PDX) mouse models. PROTAC RET Degrader 1 can be used for the study of RET-positive cancers Pink: RET ligand (HY-179308), Blue: CRBN ligand (HY-179307), Black: Linker)[1].

Product Properties

• Molecular Weight: 869.04
• CAS Number: [2760847-82-1]
• Formula: C48H57FN12O3
• Target: PROTACs,RET

Application Notes

• Application Notes: MCE Product type: Reference compound