GZD-257 is a brain-penetrant, ATP-competitive FAK inhibitor (IC50 = 14.3 nM), performing 4.77-fold selectivity with FAK to Pyk2 (IC50 = 68.2 nM). GZD-257 can significantly induce apoptosis of U118MG cells and arrest the cell cycle at the G2/M phase. GZD-257 can be used for the study of Glioblastoma (GBM)[1].
Molecular Weight:
525.00
Formula:
C26H29ClN6O4
Target:
Apoptosis,FAK,Pyk2
Application Notes:
MCE Product type: Reference compound
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