PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 µM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma[1].
Molecular Weight:
416.49
CAS Number:
[3054148-68-1]
Formula:
C20H24N4O4S
Target:
Cuproptosis,Phosphoglycerate Kinase (PGK)
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
