mTOR/GLS1-IN-1 (Compoud 9d) is a potent dual targeted mTOR/GLS1 inhibitor. Has anti proliferative activity against various tumor cells. mTOR/GLS1-IN-1 dose dependently induces ROS accumulation, induces autophagosome formation, and induces apoptosis. mTOR/GLS1-IN-1 can increase Fe2+, decrease GPX4, and induce ferroptosis. mTOR/GLS1-IN-1 can inhibit cell migration, invasion, and angiogenesis. mTOR/GLS1-IN-1 can be used in the research of cancer, such as breast cancer[1].
Molecular Weight:
1421.78
Formula:
C76H108N8O16S
Target:
Apoptosis,Autophagy,Ferroptosis,Glutaminase,Glutathione Peroxidase,mTOR,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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