HDAC-IN-94 is a potent, selective HDAC6 inhibitor (IC50 = 4.5 nM). HDAC-IN-94 shows >1000-fold selectivity over HDAC8 and shows minimal activity against other isoforms (HDAC1-3/10). HDAC-IN-94 induces alpha-tubulin hyperacetylation, apoptosis, and G2/M cell cycle arrest, exhibiting potent anti-tumor efficacy with low cytotoxicity. HDAC-IN-94 can be used for neuroblastoma and glioblastoma research[1].
Molecular Weight:
342.35
Formula:
C18H18N2O5
Target:
Apoptosis,Caspase,HDAC,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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