CDK9-IN-45 (Compound B11) is a highly selective CDK9 inhibitor with IC50 values for CDK9 and CDK1 of 7.13 and 489.5 nM respectively. CDK9-IN-45 exhibits a potent inhibitory effect on colorectal cancer cells. CDK9-IN-45 induces cell apoptosis and leads to significant accumulation of ROS. CDK9-IN-45 activates Caspase-3, downregulates Mcl-1, XIAP, and c-Myc. CDK9-IN-45 can be used for research on colorectal cancer[1].
Molecular Weight:
459.47
Formula:
C25H22FN5O3
Target:
Apoptosis,Bcl-2 Family,Caspase,CDK,c-Myc,IAP,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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