NP3-742 is an orally active NLRP3 inhibitor that binds to the NLRP3 NACHT domain. NP3-742 inhibits IL-1beta release with IC50s of 6 nM and 47 nM in both the cellular and whole blood assays, respectively. NP3-742 is highly selective against a panel of more than 50 enzymes, receptors and sodium and calcium channels. NP3-742 can be used for the study of gout, cardiovascular disease or osteoarthritis[1].
Molecular Weight:
336.43
Formula:
C19H24N6
Target:
Interleukin Related,NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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