HDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis[1].
Molecular Weight:
319.31
Purity:
95.38
CAS Number:
[3021527-82-9]
Formula:
C18H13N3O3
Target:
ERK,MEK,P2Y Receptor,PKA,Raf
Application Notes:
MCE Product type: Reference compound
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