COX-2-IN-60, CAS [[3073624-74-2]] Preis auf Anfrage

Product Overview

• Article Name: COX-2-IN-60, CAS [[3073624-74-2]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-179142
• Supplier Catalog Number: HY-179142
• Alternative Catalog Number: MCE-HY-179142-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

COX-2-IN-60 is a potent, orally active, and selective COX-2 inhibitor with an IC50 of 0.06 µM. COX-2-IN-60 exhibits ~100-fold selectivity over COX-1 (IC50 = 5.93 ). COX-2-IN-60 reduces oxidative stress and neuroinflammatory cytokines, and effectively counteracts epileptogenesis. COX-2-IN-60 exhibits significant anticonvulsant effects and protects against hippocampal injury by suppressing oxidative stress (reducing MDA and NO), pro-inflammatory signaling (reducing TNF-alpha and IL-6), and glial activationin in the Pilocarpine (HY-B0726A)-induced seizure mouse model. COX-2-IN-60 can be used for the research on neuroinflammatory and epilepsy[1].

Product Properties

• Molecular Weight: 391.22
• CAS Number: [3073624-74-2]
• Formula: C17H15BrN2O4
• Target: COX,Interleukin Related,TNF Receptor

Application Notes

• Application Notes: MCE Product type: Reference compound