AO-365/43472821, CAS [[1081122-55-5]]

Product Overview

• Article Name: AO-365/43472821, CAS [[1081122-55-5]]
• Biozol Catalog Number: MCE-HY-179177
• Supplier Catalog Number: HY-179177
• Alternative Catalog Number: MCE-HY-179177-5MG, MCE-HY-179177-10MG, MCE-HY-179177-25MG, MCE-HY-179177-50MG, MCE-HY-179177-100MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor (IC50 = 0.29 µM) and shows a significant inhibitory effect on (CDC-like kinase 1) CLK1 (IC50 = 0.08 µM). AO-365/43472821 could protect the human neuroblastoma cell line SH-SY5Y from Okadaic acid (HY-N6785) (OA)-induced injury. AO-365/43472821 decreased tau (pSer396)/tau and Abeta1-42 protein expression. AO-365/43472821 can be used for the study of Alzheimers disease[1].

Product Properties

• Molecular Weight: 412.42
• Purity: 95.24
• CAS Number: [1081122-55-5]
• Formula: C19H16N4O5S
• Target: Amyloid-beta,CDK,DYRK,Tau Protein

Application Notes

• Application Notes: MCE Product type: Reference compound1