KTT-1 is a kinetically selective and orally active HDAC2 inhibitor. KTT-1 exhibits high HDAC2-selectivity over HDAC1. KTT-1 inhibits osteoclast differentiation at an early stage by downregulating c-Fos expression. KTT-1 effectively suppresses arthritis symptoms in the collagen-induced arthritis (CIA) mouse model. KTT-1 can be used for the research of rheumatoid arthritis and neurodegenerative diseases[1][2].
Molecular Weight:
499.54
CAS Number:
[2397562-26-2]
Formula:
C26H21N5O4S
Target:
HDAC
Application Notes:
MCE Product type: Reference compound1
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