RTx-303 is an orally active, selective DNA polymerase theta (Poltheta) inhibitor (IC50 = 5.1 nM). RTx-303 exhibits significantly high cellular potency and strongly potentiates PARPi in BRCA1/2 mutant cells and patient-derived xenograft models. RTx-303 can be used for the study of BRCA2-mutated breast cancer[1].
Molecular Weight:
569.49
CAS Number:
[3035072-99-9]
Formula:
C24H22D3F7N4O4
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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