AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer[1].
Molecular Weight:
344.23
CAS Number:
[1246964-08-8]
Formula:
C19H15Cl2NO
Target:
CTLA-4,TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound1
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