FTO-IN-15 (Compound 8a) is a potent and selective dual-competitive FTO inhibitor with an IC50 of 43.7 nM, showing high selectivity over ALKBH3 and ALKBH5. FTO-IN-15 substantially inhibits FTO demethylation by simultaneously occupying the substrate and 2-oxoglutarate (2-OG) pockets. FTO-IN-15 can be used for the research of acute myeloid leukemia (AML)[1].
Molecular Weight:
466.27
Formula:
C20H17Cl2N3O6
Target:
Fat Mass and Obesity-associated Protein (FTO)
Application Notes:
MCE Product type: Reference compound1
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