TPST2-IN-1 is a potent and selective TPST2 inhibitor with an IC50 of 946 nM and a Ka of 19.4 µM. TPST2-IN-1 increases the phosphorylation of Stat1 and upregulates the IFNgamma-responsive gene CXCL10 by inhibiting TPST2 activity.TPST2-IN-1 exhibits anti-tumor activity and enhances T cell-mediated antitumor immunity characterized by increased infiltration of effector CD8+ T cells. TPST2-IN-1 can be used for the research of cancer, such as colon cancer[1].
Molecular Weight:
612.69
Formula:
C31H34F2N4O5S
Target:
STAT,Transmembrane Glycoprotein
Application Notes:
MCE Product type: Reference compound1
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