DPP9-IN-2 is a selective, potent and orally active inhibitor of Dipeptidyl Peptidase 9 (DPP9 ) with an IC50 of 12.9 nM. DPP9-IN-2 shows a SI of 59 over DPP8, and shows no significant inhibitory activity against related peptidases including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce cancer cells pyroptosis and has weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitor. DPP9-IN-2 can be used for the researches of cance rand infection[1].
Molecular Weight:
541.63
CAS Number:
[3020859-44-0]
Formula:
C33H33F2N3O2
Target:
Dipeptidyl Peptidase,HIV,Pyroptosis
Application Notes:
MCE Product type: Reference compound
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