TSI-13-57 is a pan-TLR inhibitor (IC50: 2.7 µM, 6.03 µM, 7.37 µM, 6.38 µM for TLR9, TLR7, TLR2, TLR4, respectively). TSI-13-57 inhibits homodimerization of the TIR domains of MyD88. TSI-13-57 reduces systemic inflammatory responses in LPS-induced mice[1][2].
Molecular Weight:
455.55
CAS Number:
[2257427-45-3]
Formula:
C28H29N3O3
Target:
MyD88,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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