KRASG12C IN-19, CAS [[2915282-32-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-179484
Supplier Catalog Number:
HY-179484
Alternative Catalog Number:
MCE-HY-179484-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
KRASG12C IN-19 is a selective and orally active KRASG12C inhibitor. KRASG12C IN-19 exerts potent antiproliferative activity against the KRASG12C-mutant non small cell lung cancer (NSCLC) cell line H358 with an IC50 of 7.6 nM, and effectively suppresses downstream ERK phosphorylation (IC50 = 24.06 nM). KRASG12C IN 19 has no significant inhibitory activity against KRASG12V and KRASG12D-mutant cancer cells (PANC 1, Panc, AsPC 1, and GP2d cells) with IC50 > 10,000 nM. KRASG12C IN-19 rapidly forms a covalent bond with KRASG12V-GDP, leading to dose-dependent inhibition of the downstream KRAS pathway. KRASG12C IN 19 can be employed for research in KRASG12C driven cancers, including non small cell lung cancer, pancreatic cancer, and colorectal cancer[1].
Molecular Weight:
590.65
CAS Number:
[2915282-32-3]
Formula:
C33H31FN8O2
Target:
ERK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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