M464, a non-steroidal anti-inflammatory compound, is a potent and orally active NLRP3 inflammasome inhibitor. M464 inhibits pyroptosis and hinders the activation of downstream Caspase-1 expression and the release of IL-1beta by impeding ASC oligomerisation and curtailing ROS production. M464 exhibits protective effects against acute lung and liver injury in mice. M464 can be used for the research of NLRP3-related inflammatory diseases[1].
Molecular Weight:
464.66
Purity:
99.58
Formula:
C23H28O4S3
Target:
Caspase,Interleukin Related,NOD-like Receptor (NLR),Pyroptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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