EGFR/InhA-IN-1 (Compound 15) is an inhibitor of the anti-cancer target EGFR tyrosine kinase (1M17) (Ki = 0.05 µM) and the anti-tuberculosis target InhA enzyme (1OUZ) (Ki = 0.02 µM). EGFR/InhA-IN-1 exhibits anti-proliferative activity against A549 cells, with an IC50 of 10.38 µM. EGFR/InhA-IN-1 has inhibitory activity against Mycobacterium tuberculosis H37Rv, with a MIC of 6.25 µM. EGFR/InhA-IN-1 can be used for research on non-small cell lung cancer and Mycobacterium tuberculosis infection[1].
Molecular Weight:
448.90
Formula:
C27H17ClN4O
Target:
Bacterial,EGFR
Application Notes:
MCE Product type: Reference compound
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