RWT9996 is a balanced GPR17 antagonist. RWT9996 has an inhibitory effect on G protein activation and beta-arrestin-2 recruitment induced by MDL-29951. RWT9996 inhibits the phosphorylation of ERK/CREB and the accumulation of inositol phosphate (b IP1) induced by MDL-29951. RWT9996 can be used for the study of neurological diseases[1].