NDM-1-IN-11 is a potent covalent NDM-1 inhibitor with an IC50 of 1.12 µM, which acts by forming a Se-S bond with the enzyme. NDM-1-IN-11 effectively suppresses the growth of NDM-1-producing E. coli in both in vivo and in vitro models when combined with Meropenem (HY-13678). NDM-1-IN-11 can be used for addressing NDM-1 driven bacterial resistance[1].
Molecular Weight:
519.38
Formula:
C26H17FN2O4Se
Target:
Bacterial,Beta-lactamase
Application Notes:
MCE Product type: Reference compound
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