ZS34 is a potent, orally active, and selective MAT2A inhibitor with an IC50 of 13.7 nM, displaying minimal hERG and UGT1A1 liabilities. ZS34 selectively suppresses the growth of methylthioadenosine phosphorylase (MTAP)-deficient cancer cells by inhibiting SAM synthesis, reducing SDMA levels, and inducing DNA damage. ZS34 exhibits antitumor efficacy in a HCT116 MTAP-/- xenograft mouse model. ZS34 can be used for the research of MTAP-deficient cancer[1].
Molecular Weight:
339.78
CAS Number:
[3106086-17-0]
Formula:
C18H14ClN3O2
Target:
Methionine Adenosyltransferase (MAT)
Application Notes:
MCE Product type: Reference compound
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