PI3Kalpha-IN-29 is a potent, orally active and selective PI3Kalpha with an IC50 of 2.5 nM. PI3Kalpha-IN-29 exhibits >400-fold selectivity over PI3Kbeta/delta/gamma/mTOR. PI3Kalpha-IN-29 selectively degrades the H1047R mutant p110alpha protein and inhibits PI3Kalpha kinase activity. PI3Kalpha-IN-29 suppresses PI3K/AKT/mTOR signaling, induces G1 arrest, and inhibits migration. PI3Kalpha-IN-29 inhibits tumor growth in a T47 mouse model. PI3Kalpha-IN-29 can be used for the research of breast cancer[1].
Molecular Weight:
391.38
Formula:
C20H17N5O4
Target:
Akt,Cadherin,CDK,mTOR,PI3K
Application Notes:
MCE Product type: Reference compound
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