SK5527 is a selective AURKA PROTAC degrader degrading AURKA with DC50 = 2 nM. SK5527 bind to NanoLuc-AURKA with an IC50 of 20 nM. SK5527 effectively reduces MYCN levels in MYCN-amplified neuroblastoma cells and limited by MDR1-mediated efflux. SK5527 efficiently reduced AURKA levels in vivo. SK5527 can be used for neuroblasto2ma research[1].
Molecular Weight:
848.36
Formula:
C42H49ClF3N11O3
Target:
Aurora Kinase,PROTACs
Application Notes:
MCE Product type: Reference compound
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