NIK-IN-3 is a potent and orally active NF-kappaB-inducing kinase (NIK) inhibitor with an IC50 of 5.2 nM. NIK-IN-3 suppresses non-canonical NF-kappaB pathway activation and inhibits the secretion of pro-inflammatory cytokines, such as TNF-alpha, IL-6, IL-1beta and chemokine CXCL12. NIK-IN-3 shows significant anti-inflammatory effects in LPS (HY-D1056)-induced sepsis mice model and DSS (HY-116282)-induced colitis model. NIK-IN-3 can be used for the research of inflammation, such as colitis[1].
Molecular Weight:
522.02
Formula:
C25H24ClN7O2S
Target:
CXCR,Interleukin Related,NF-kappaB,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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