SET-12 is an antiparasitic agent with high activity and selectivity against the Leishmania amazonensis. SET-12 exhibits excellent activity against the pre-flagellated form of the Leishmania amazonensis, with an IC50 of 10.89 µM and a selectivity index (SI) of up to 12.1. SET-12 is also effective against the non-flagellated form within cells, with an IC50 of 3.81 µM and a further increased selectivity index (SI) to 34.5. SET-12 causes signs of parasite cell apoptosis, including mitochondrial damage and accumulation of ROS[1].
Molecular Weight:
359.46
CAS Number:
[2241572-39-2]
Formula:
C21H29NO4
Target:
Apoptosis,DNA/RNA Synthesis,Parasite,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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