PROTAC JAK1/2 degrader-1 (Compound A8) is a selective JAK1/2 PROTAC degrader, with DC50 values of 1.4 µM for JAK1 and 0.92 µM for JAK2. PROTAC JAK1/2 degrader-1 significantly inhibits the release of NO, IL-6 (IC50 = 12.89 µM) and TNF-alpha (IC50 = 17.17 µM). PROTAC JAK1/2 degrader-1 significantly alleviates inflammatory responses and colonic damage by inhibiting the JAK/STAT3 signaling pathway. PROTAC JAK1/2 degrader-1 can be used for research on colitis. (Pink: JAK1/2 ligand (HY-179716), Blue: CRBN ligand (HY-10984), Black: linker, CRBN ligand + linker (HY-131888A))[1].
Molecular Weight:
603.63
Formula:
C33H29N7O5
Target:
Interleukin Related,JAK,PROTACs,STAT,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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